With Crystalline, you can add capabilities such as Particle Imaging and real-time Raman and Particle Size Distribution Analysis to your crystallization process monitoring and formulation studies.

OVERVIEW

Optimize your crystallization process at an early stage with only small amount of material. The Crystalline with through the vial analytical capabilities like turbidity, particle visualization or Raman is easy to set up and operate.

The ergonomic design and effortless operation removes all the barriers to using technology which was previously only accessible to experts. The intuitive control and analysis software gives every user access to valuable information with small amounts of material.

No insert probes into reaction vessel and no cross contamination.

OPTIONS

Crystalline Standard Edition

  • 8 Reactors with a working volume of 1-5 mL
  • 8 Independently controlled temperature zones
  • Temperature range -25°C to 150°C
  • Linear and non-linear temperature profiles supported
  • 0°-20°C/min heating/cooling rate
  • Temperature control accuracy: 0.1°C
  • Variable overhead stirring in each reactor
  • Variable magnetic stirring in each reactor
  • Stirrer speed: 0 – 1250 rpm
  • Turbidity measurement in each reactor
  • Reflux, slow evaporation, anti-solvent and seeding capabilities

Crystalline Particle Viewer

  • Crystalline SE
  • 4 or 8 parallel visualization probes
  • Sample illumination: front and back pulsed lighting
  • Automatic light intensity control
  • Each camera is individually controlled and programmable
  • Image analysis software: particle size distribution and shape

Crystalline Raman Ready

  • Crystalline SE
  • 4 parallel real time Raman probes
  • Correlation of Raman spectra with temperature profiles and turbidity signals
  • Software interface for spectroscopic analysis

 

TECHNICAL INFORMATION

The complete Crystalline series are desktop instruments taking up very little of your valuable laboratory space. With a footprint of only 310 x 420 mm, the Crystalline SE will fit onto any workbench.

A Crystalline will hold up to 8 standard disposable glass vials (16,6 mm diameter, flat bottomed, 8 ml volume).

Each reactor can be independently loaded, programmed and operated. Magnetic flux rotation with programmable stir speeds allows for both overhead stirring and mixing using magnetic stirrer bars.

In order to prevent condensation on the reactor blocks and electronics during runs at temperatures below 10°C the Crystalline system provides an inlet for a dry purge gas (typically nitrogen).

DOCUMENTS