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- CrystalBreeder
CrystalBreeder is a next generation crystallization monitoring system that can be used in the early stages of solid dosage form research.
OVERVIEW
The CrystalBreeder is the next generation multi-reactor crystallization platform for medium-throughput solid-state research, operating at a working volume of 0.1 mL. Carry out rapid complete crystallization screens with as little as 1 mg of sample. The CrystalBreeder gives you real time turbidity information for 32 parallel temperature controlled experiments. When early solubility information is essential, stop guessing and allow the CrystalBreeder to put you in the lead.
The CrystalBreeder takes the guesswork out of solid-state screening. The crystallization space can be systematically explored with the ability to control temperature profiles, stirring speed and crystallization mode. Whether you are searching for new polymorphs, or doing salt or co-crystal screens, the turbidity signal gives you a clear indication of a hit. The compatible software makes it effortless to scale up to a milliliter scale for solubility studies or MSZW determination by using the Crystal16® or Crystalline.
FEATURES
Multiple crystallization modes
Cooling, evaporation, slurry, thermocycling, vapor diffusion.
Advanced features
Integrated air-cooling. Eliminate the need for messy chillers or a house water supply. Extended temperature range from -15°C to 150°C.
Minimal sample required
Less than 32 mg of sample for a complete screen.
Up to 32 parallel reactors
Carry out a complete salt, co-crystal or polymorph screen overnight.
TECHNICAL SPECIFICATIONS
Operating Parameters
| Reactors | 32 |
| Reactor type | Commercially available, glass |
| Optimum working volume (ml) | 0,05 ila 0,25 |
| Temperature zones | 8 |
| Temperature range (°C) | (-15) - 150 |
| Temperature accuracy (°C) | 0.1 |
| Heating/cooling (°C/min) | 0 - 20 |
| Mixing | Overhead |
| Mixing speed (rpm) | 0 - 1250 |
| Turbidity (%) | Every reactor |
| Cooler required | No |
| Data export | CrystalClear, Word report, xml |
| Footprint (DxWxH in cm) | 49x56x20 |
| Temperature profile | unlimited heating/cooling/hold steps per run programmable |